We have built up specialist knowledge and expertise on RGD integrin drug discovery with an extensive publication track record. As the chemotypes are zwitterions they are atypical small molecules. Our achievements and skills include:

  • Small molecule RGD integrin inhibitor drug design
  • Studies required for candidate selection
  • Delivered multiple clinical candidates in the RGD integrin field
  • Experience of different modes of delivery (oral, iv, inhaled, long acting parenteral)
  • Expert knowledge of available integrin tools and probes for biological studies
  • Up-to-date competitor knowledge and patents
  • Appropriate screening assays
  • Application to the treatment of fibrotic diseases and cancer

See our review on Integrin drug discovery

An αv-​RGD integrin inhibitor toolbox: drug discovery insight, challenges and opportunities. Hatley, Richard; Macdonald, Simon; Le, Joelle; Ludbrook, Steve; Lukey, Pauline; Slack, Robert;
Angew Chem Int Ed Engl. 2018, 57, 3298-3321.
Copyright Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission