We have wide experience and an extensive track record in drug discovery.  We have contributed to and led numerous programmes in the delivery of clinical candidates, been cited as inventors on over 40 patents and  published ~120 peer reviewed articles and reviews. 

Areas of expertise:

  • All phases of medicinal chemistry in drug discovery • Chemical tools & probes  • Triage strategies • Hit to lead • Lead optimisation • Candidate selections • Clinical compounds
  • Therapeutic areas • Fibrotic diseases  • Anti-virals • Anti-inflammatories  • Respiratory  • Malaria • Cardiovascular • Neuroscience
  • Synthesis • Large and small molecules • Mono- and multivalent inhibitors • Covalently bound and non-covalently bound inhibitors • Inhibitors of cell surface receptors • Array design • Large and small scale route design
  • Multiple routes of administration • The inhaled route • The oral route • Long acting parenterals (injection of microparticles)
  • Current medicinal chemistry design principles • Physicochemical properties • Design and visualisation tools • SAR • Iterative medchem
  • The art of writing papers and publishing
  • Bibliometric analyses

Examples of medicinal chemistry projects that we have worked on…

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