We have wide experience and an extensive track record in drug discovery.  We have contributed to and led numerous programmes in the delivery of clinical candidates, been cited as inventors on over 40 patents and  published ca 120 peer reviewed articles and reviews


  • We have been involved in all phases of medicinal chemistry • Chemical tools & probes  • Triage strategies • Hit to lead • Lead optimisation • Candidate selections • Clinical compounds
  • We have delivered in many therapeutic areas • Fibrotic diseases  • Anti-virals • Anti-inflammatories  • Respiratory  • Malaria • Cardiovascular • Neuroscience
  • We have made • Large and small molecules • Mono- and multivalent inhibitors • Covalently bound and non-covalently bound inhibitors • Inhibitors of cell surface receptors
  • The compounds of our drug discovery projects have been administered by • The inhaled route • The oral route • Long acting parenterals (injection of microparticles)
  • Implementation of current medicinal chemistry design principles to advance projects • Physicochemical properties • Design and visualisation tools
  • We have written or co-written well cited papers on advancing the art of drug discovery, particularly on • Careful and judicious use of tools • Analysis of carbo- and heteroaromatic rings in drug discovery to improve compound developability

Examples of medicinal chemistry projects that we have worked on…

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