Medicinal chemistry 

• Path and progression to clinical quality compounds
• Hit identification • Hit to lead • Lead optimisation • Candidate selections
• Expertise across: Multiple target classes •  Triage strategies • Screening strategies

Drug design principles

• Use of current physicochemical properties and molecular descriptors in drug design
• In silico methods and data visualisation • SAR • Iterative and multi-parameter optimisation

Multiple disease areas

• Fibrotic diseases • Viruses • Inflammation • Respiratory diseases
• Cancer • Cardiovascular • Neuroscience • Diseases of the 3rd world

Synthetic chemistry 

• Route planning and synthesis
• Array design
• Large and small scale route design of complex molecules
• Work with CROs to synthesise compounds

Tools, Modalities and Administration routes 

• Chemical tools & probes • Large (bRo5) and small molecules (Ro5) • conjugates • mono- and multivalent inhibitors     
• Covalently bound and non-covalently bound inhibitors • Intracellular and extracellular targets
• Inhaled route • oral route • long acting parenteral route (injection of microparticles)

Additional areas of expertise

• The art of writing papers and publishing
• Bibliometric analyses
• Integrin drug discovery
• Undergraduate teaching modules
• Patents – analysis • strategy • reports • expert witness
• Identifying the market opportunity
• Due diligence 

Tailored reporting output⇒

• Detailed reports
• Presentations​
• Discussion and collaborations
• High value contributions
• Literature analyses
• Prioritisation of the best work streams and approaches
• Identify the best experiments to undertake
• Patent assessment and molecule analysis