Drug discovery consultancy expertise

Medicinal chemistry 
  • Path and progression to clinical quality compounds
  • Hit identification • Hit to lead • Lead optimisation • Candidate selections
  • Multiple target classes •  Triage strategies • Screening strategies
Drug design principles
  • Use of current physicochemical properties and molecular descriptors in drug design
  • In silico methods and data visualisation • SAR • Iterative and multi-parameter optimisation
Multiple disease areas
  • Fibrotic diseases • Viruses • Inflammation • Respiratory diseases
  • Cancer • Cardiovascular • Neuroscience • Diseases of the 3rd world
Synthetic chemistry 
  • Route planning and synthesis
  • Array design
  • Large and small scale route design of complex molecules
  • Work with CROs to synthesise compounds
Tools, Modalities and Administration routes 
  • Chemical tools & probes • Large (bRo5) and small molecules (Ro5) • conjugates • mono- and multivalent inhibitors     
  • Covalently bound and non-covalently bound inhibitors • Intracellular and extracellular targets
  • Inhaled route • oral route • long acting parenteral route (injection of microparticles)
Additional areas of expertise
  • The art of writing papers and publishing
  • Bibliometric analyses
  • Integrin drug discovery
  • Undergraduate teaching modules
  • Patents – analysis • strategy • reports • expert witness
  • Identifying the market opportunity
  • Due diligence 

Tailored reporting output⇒

  • Detailed reports
  • Presentations​
  • Discussion and collaborations
  • High value contributions
  • Literature analyses
  • Prioritisation of the best work streams and approaches
  • Identify the best experiments to undertake
  • Patent assessment and molecule analysis
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