All phases of medicinal chemistry in drug discovery

  • Many target classes • Chemical tools & probes  • Triage strategies
  • Hit to lead • Lead optimisation • Candidate selections
  • Clinical compounds
  • Developability criteria

Multiple disease areas

  • Fibrotic diseases • Viruses • Inflammation • Respiratory
  • Cancer • Cardiovascular • Neuroscience • Diseases of the 3rd world

Synthetic chemistry 

  • Route planning and synthesis
  • Array design
  • Large and small scale route design of complex molecules
  • Working with CROs to obtain compounds

Modalities and administration routes 

  • Large and small molecules • conjugates • mono- and multivalent inhibitors 
  • Inhaled route • oral route • long acting parenterals (injection of microparticles)    
  • Covalently bound and non-covalently bound inhibitors • Intracellular and extracellular targets

Drug design principles

  • Physicochemical properties • molecular descriptors
  • Design and visualisation tools • SAR • iterative medchem processes

Additional areas of expertise

  • The art of writing papers and publishing
  • Bibliometric analyses
  • Integrin drug discovery
  • Undergraduate teaching modules
  • Patents – analysis • strategy • reports • expert witness
  • Identifying the market opportunity
  • Due diligence 

Output⇒

  • Detailed reports
  • Presentations​
  • Discussion
  • High value contributions
  • Literature analyses
  • Prioritising work streams
  • Identify the best experiments to undertake