Drug Discovery consultancy expertise
Multiple disease areas
  • Cancer • Neuroscience • Cardiovascular • Diseases of the developing world • Fibrotic diseases • Viruses • Inflammation • Respiratory diseases
Medicinal chemistry 
  • Path and progression to clinical quality compounds
  • Hit identification • Hit to lead • Lead optimisation • Candidate selections
  • Multiple target classes •  Triage strategies • Screening strategies
  • Prioritisation of series
Drug design principles
  • Use of current physicochemical properties and molecular descriptors in drug design
  • In silico methods and data visualisation • SAR • Iterative and multi-parameter optimisation
Tools, Modalities and DMPK
  • Protein-protein interactions
  • Chemical tools & probes • Large (bRo5) and small molecules (Ro5) • conjugates • mono- and multivalent ligands  
  • Covalently bound and non-covalently bound inhibitors • Intracellular and extracellular targets
  • DMPK profiling and interpretation. Assessment of routes of administration
Synthetic chemistry 
  • Route planning and synthesis
  • Array design
  • Large and small scale route design of complex molecules
  • Work with CROs to synthesise compounds
Patents & Due diligence
  • Strategy
  • Scientific content
  • Analysis
  • Detailed assessment of projects
High quality tailored reporting output
  • Detailed reports
  • Presentations​
  • Discussion and collaborations
  • Multiple approaches with prioritisation
  • Literature analyses
  • Screening cascades
  • Identify the best experiments to undertake
  • Patent assessment and molecule analysis