Drug discovery consultancy expertise

Medicinal chemistry 

  • Path and progression to clinical quality compounds
  • Hit identification • Hit to lead • Lead optimisation • Candidate selections
  • Expertise across: Multiple target classes •  Triage strategies • Screening strategies

Drug design principles

  • Use of current physicochemical properties and molecular descriptors in drug design
  • In silico methods and data visualisation • SAR • Iterative and multi-parameter optimisation

Multiple disease areas

  • Fibrotic diseases • Viruses • Inflammation • Respiratory diseases
  • Cancer • Cardiovascular • Neuroscience • Diseases of the 3rd world

Synthetic chemistry 

  • Route planning and synthesis
  • Array design
  • Large and small scale route design of complex molecules
  • Work with CROs to synthesise compounds

Tools, Modalities and Administration routes 

  • Chemical tools & probes • Large (bRo5) and small molecules (Ro5) • conjugates • mono- and multivalent inhibitors     
  • Covalently bound and non-covalently bound inhibitors • Intracellular and extracellular targets
  • Inhaled route • oral route • long acting parenteral route (injection of microparticles)

Additional areas of expertise

  • The art of writing papers and publishing
  • Bibliometric analyses
  • Integrin drug discovery
  • Undergraduate teaching modules
  • Patents – analysis • strategy • reports • expert witness
  • Identifying the market opportunity
  • Due diligence 

Tailored reporting output⇒

  • Detailed reports
  • Presentations​
  • Discussion and collaborations
  • High value contributions
  • Literature analyses
  • Prioritisation of the best work streams and approaches
  • Identify the best experiments to undertake
  • Patent assessment and molecule analysis