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Drug discovery consultancy expertise
Medicinal chemistry
- Path and progression to clinical quality compounds
- Hit identification • Hit to lead • Lead optimisation • Candidate selections
- Expertise across: Multiple target classes • Triage strategies • Screening strategies
Drug design principles
- Use of current physicochemical properties and molecular descriptors in drug design
- In silico methods and data visualisation • SAR • Iterative and multi-parameter optimisation
Multiple disease areas
- Fibrotic diseases • Viruses • Inflammation • Respiratory diseases
- Cancer • Cardiovascular • Neuroscience • Diseases of the 3rd world
Synthetic chemistry
- Route planning and synthesis
- Array design
- Large and small scale route design of complex molecules
- Work with CROs to synthesise compounds
Tools, Modalities and Administration routes
- Chemical tools & probes • Large (bRo5) and small molecules (Ro5) • conjugates • mono- and multivalent inhibitors
- Covalently bound and non-covalently bound inhibitors • Intracellular and extracellular targets
- Inhaled route • oral route • long acting parenteral route (injection of microparticles)
Additional areas of expertise
- The art of writing papers and publishing
- Bibliometric analyses
- Integrin drug discovery
- Undergraduate teaching modules
- Patents – analysis • strategy • reports • expert witness
- Identifying the market opportunity
- Due diligence
Tailored reporting output⇒
- Detailed reports
- Presentations
- Discussion and collaborations
- High value contributions
- Literature analyses
- Prioritisation of the best work streams and approaches
- Identify the best experiments to undertake
- Patent assessment and molecule analysis