A potential role for RGD integrins in host cell entry by COVID-19?
The RGD integrins may be another druggable target (in addition to ACE-2) that prevents cell entry by COVID-19
A combination of check point inhibitors and avb8 inhibition
This could initiate further research into finding effective treatments for cancer
selective avb3 antagonist
This work could significantly further our understanding of integrin signalling. It will be very interesting to observe if this is shown for the other integrin proteins.